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Phenoxide chelated Ir(III) N-heterocyclic carbene complexes: synthesis, characterization, and evaluation of their in vitro anticancer activity

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Abstract

Twelve novel half-sandwich IrIII–NHC complexes [(η5-Cpx)Ir(C^O)Cl] were synthesized and characterized. These complexes showed higher cytotoxic activity toward A549 cells and HeLa cells than cisplatin. An increase in the number of contained phenyl groups was related to better anticancer activity. The reaction of complexes with nucleobases 9-MeA, nucleobases 9-EtG, plasmid DNA and CT-DNA showed no significant effects. These complexes captured hydrogen from NADH and converted it to NAD+, which produced the reactive oxygen species (ROS). ROS led to a decrease in the mitochondrial membrane potential and lysosomal damage, finally inducing apoptosis.

Graphical abstract: Phenoxide chelated Ir(iii) N-heterocyclic carbene complexes: synthesis, characterization, and evaluation of their in vitro anticancer activity

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Publication details

The article was received on 02 Aug 2018, accepted on 06 Sep 2018 and first published on 06 Sep 2018


Article type: Communication
DOI: 10.1039/C8DT03159B
Citation: Dalton Trans., 2018, Advance Article
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    Phenoxide chelated Ir(III) N-heterocyclic carbene complexes: synthesis, characterization, and evaluation of their in vitro anticancer activity

    Y. Zhang, S. Zhang, Z. Tian, J. Li, Z. Xu, S. Li and Z. Liu, Dalton Trans., 2018, Advance Article , DOI: 10.1039/C8DT03159B

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