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Pre-/Post-functionalization in Dipyrrin Metal Complexes – Antitumor and Antibacterial Activity of their Glycosylated Derivatives

Abstract

A post-functionalization route to tris(dipyrrinato) metal complexes is presented giving access to a range of new complexes relevant in the context of medicinal inorganic chemistry. A pentafluorophenyl group in the meso-position of the dipyrrin ligand serves as an anchor for the connection with alcohols and thiocarbohydrates. The photochemotherapeutic activity of the complexes has been assessed in cellular assays with tumor cell lines and against the Gram-positive bacterium S. aureus. Finally, it is shown that this post-functionalization is also applicable to other dipyrrinato metal complexes.

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Publication details

The article was received on 26 Jul 2018, accepted on 08 Aug 2018 and first published on 08 Aug 2018


Article type: Paper
DOI: 10.1039/C8DT03059F
Citation: Dalton Trans., 2018, Accepted Manuscript
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    Pre-/Post-functionalization in Dipyrrin Metal Complexes – Antitumor and Antibacterial Activity of their Glycosylated Derivatives

    A. Wiehe, C. S. Gutsche, S. Gräfe, B. Gitter, K. Flanagan, M. Senge and N. Kulak, Dalton Trans., 2018, Accepted Manuscript , DOI: 10.1039/C8DT03059F

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