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Issue 37, 2018
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Tracking mitochondrial dynamics during apoptosis with phosphorescent fluorinated iridium(III) complexes

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Abstract

Mitochondria are the control centers of apoptosis. To study mitochondrial dynamics during apoptosis, four phosphorescent fluorinated iridium(III) complexes (Ir1–Ir4) were designed and synthesized. The complexes' emission maxima, phosphorescent quantum yields, and phosphorescent lifetimes are tuned by the degree of fluorination of the ligand. The complexes exhibit excellent photostability and low (photo)cytotoxicity in HeLa cells. As the complexes are cationic and lipophilic, they localize in mitochondria and enter cells through an energy-independent pathway. In comparison with commercially available mitochondrial trackers (e.g., MTR), Ir1–Ir4 exhibit high specificity to mitochondria even in fixed cells. Due to these outstanding properties, the complexes were successfully used to track mitochondrial dynamics during apoptosis.

Graphical abstract: Tracking mitochondrial dynamics during apoptosis with phosphorescent fluorinated iridium(iii) complexes

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Publication details

The article was received on 17 Jul 2018, accepted on 06 Aug 2018 and first published on 07 Aug 2018


Article type: Paper
DOI: 10.1039/C8DT02918K
Citation: Dalton Trans., 2018,47, 12907-12913
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    Tracking mitochondrial dynamics during apoptosis with phosphorescent fluorinated iridium(III) complexes

    C. Zhang, K. Qiu, C. Liu, H. Huang, T. W. Rees, L. Ji, Q. Zhang and H. Chao, Dalton Trans., 2018, 47, 12907
    DOI: 10.1039/C8DT02918K

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