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Turning intercalators into groove binders: synthesis, photophysics and DNA binding properties of tetracationic mononuclear Ruthenium(II)-based chromophore-quencher complexes

Abstract

The synthesis of two new tetracationic mononuclear RuII complexes containing the tetrapyridyl [3,2-a:2',3'-c:3'',2''-h:2''',3'''-j] phenazine ligand in which the uncoordinated site has been converted into a dicationic ethylene-bipyridyldiylium unit is reported. The structure of the complexes is fully assigned through detailed NMR studies and, in one case, through an X-ray crystallography study. Voltammetry, optical spectroscopy and computational studies confirm that the bipyridyldiylium moiety has a low-lying reduction that quenches the 3MLCT-based emission usually observed in such systems. The new complexes interact with DNA in a quite different manner to their dicationic analogues: they both bind to duplex DNA with micromolar affinity through groove binding. These observations are rationalized through a consideration of their structural and electronic properties

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Publication details

The article was received on 28 Jun 2018, accepted on 26 Jul 2018 and first published on 10 Aug 2018


Article type: Paper
DOI: 10.1039/C8DT02633E
Citation: Dalton Trans., 2018, Accepted Manuscript
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    Turning intercalators into groove binders: synthesis, photophysics and DNA binding properties of tetracationic mononuclear Ruthenium(II)-based chromophore-quencher complexes

    H. Derrat, C. C. Robertson, A. J. H. M. Meijer and J. A. Thomas, Dalton Trans., 2018, Accepted Manuscript , DOI: 10.1039/C8DT02633E

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