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Ferritin encapsulation of artificial metalloenzymes: engineering a tertiary coordination sphere for an artificial transfer hydrogenase

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Abstract

Ferritin, a naturally occuring iron-storage protein, plays an important role in nanoengineering and biomedical applications. Upon iron removal, apoferritin was shown to allow the encapsulation of an artificial transfer hydrogenase (ATHase) based on the streptavidin-biotin technology. The third coordination sphere, provided by ferritin, significantly influences the catalytic activity of an ATHase for the reduction of cyclic imines.

Graphical abstract: Ferritin encapsulation of artificial metalloenzymes: engineering a tertiary coordination sphere for an artificial transfer hydrogenase

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Publication details

The article was received on 31 May 2018, accepted on 10 Jul 2018 and first published on 11 Jul 2018


Article type: Communication
DOI: 10.1039/C8DT02224K
Citation: Dalton Trans., 2018, Advance Article
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    Ferritin encapsulation of artificial metalloenzymes: engineering a tertiary coordination sphere for an artificial transfer hydrogenase

    M. Hestericová, T. Heinisch, M. Lenz and T. R. Ward, Dalton Trans., 2018, Advance Article , DOI: 10.1039/C8DT02224K

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