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Issue 22, 2018
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DNA interactions of non-chelating tinidazole-based coordination compounds and their structural, redox and cytotoxic properties

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Abstract

Novel tinidazole (tnz) coordination compounds of different geometries were synthesised, whose respective solid-state packing appears to be driven by inter- and intramolecular lone pair⋯π interactions. The copper(II) compounds exhibit interesting redox properties originating from both the tnz and the metal ions. These complexes interact with DNA through two distinct ways, namely via electrostatic interactions or/and groove binding, and they can mediate the generation of ROS that damage the biomolecule. Cytotoxic studies revealed an interesting activity of the dinuclear compound [Cu(tnz)2(μ-Cl)Cl]27, which is further more efficient towards cancer cells, compared with normal cells.

Graphical abstract: DNA interactions of non-chelating tinidazole-based coordination compounds and their structural, redox and cytotoxic properties

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Article information


Submitted
22 Feb 2018
Accepted
09 May 2018
First published
09 May 2018

Dalton Trans., 2018,47, 7551-7560
Article type
Paper

DNA interactions of non-chelating tinidazole-based coordination compounds and their structural, redox and cytotoxic properties

R. Castro-Ramírez, N. Ortiz-Pastrana, A. B. Caballero, M. T. Zimmerman, B. S. Stadelman, A. A. E. Gaertner, J. L. Brumaghim, L. Korrodi-Gregório, R. Pérez-Tomás, P. Gamez and N. Barba-Behrens, Dalton Trans., 2018, 47, 7551
DOI: 10.1039/C8DT00716K

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