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Engineering P450LaMO Stereospecificity and Product Selectivity for Selective C-H Oxidation of Tetralin-like Alkylbenzenes

Abstract

Via Phenylalanine scanning and with further protein engineering to reshap the active pocket of P450LaMO, the resulting mutant (T121V/Y385F/M391L) for tetralin shows improved (S)-enantioselectivity (er 66:34 to 98:2) and excellent product-selectivity (the ratio of alcohol and ketone, ak 76:24 to 99:1).

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Publication details

The article was received on 12 Jul 2018, accepted on 03 Aug 2018 and first published on 03 Aug 2018


Article type: Paper
DOI: 10.1039/C8CY01448E
Citation: Catal. Sci. Technol., 2018, Accepted Manuscript
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    Engineering P450LaMO Stereospecificity and Product Selectivity for Selective C-H Oxidation of Tetralin-like Alkylbenzenes

    R. Li, A. Li, J. Zhao, Q. Chen, N. Li, H. Yu and J. Xu, Catal. Sci. Technol., 2018, Accepted Manuscript , DOI: 10.1039/C8CY01448E

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