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Issue 23, 2018
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Application of (4+3) cycloaddition strategies in the synthesis of natural products

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Abstract

(4+3) Cycloadditions have been widely applied in synthesis, and in this review article, we summarize some of the more recent applications, including formal (4+3) cycloadditions, in the synthesis of natural products. Many of these natural product target frameworks have cycloheptane subunits, for which the (4+3) cycloaddition is a convergent strategy for their assembly. Some natural product targets do not possess seven membered rings, and their syntheses have exploited the functional group endowed (4+3) cycloadducts resulting from these reactions, highlighting the utility of this methodology for the synthesis of a range of complex molecules.

Graphical abstract: Application of (4+3) cycloaddition strategies in the synthesis of natural products

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Publication details

The article was received on 30 Jun 2018 and first published on 05 Nov 2018


Article type: Review Article
DOI: 10.1039/C8CS00532J
Citation: Chem. Soc. Rev., 2018,47, 8881-8924

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    Application of (4+3) cycloaddition strategies in the synthesis of natural products

    Z. Yin, Y. He and P. Chiu, Chem. Soc. Rev., 2018, 47, 8881
    DOI: 10.1039/C8CS00532J

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