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Issue 5, 2018
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Chemical strategies to unravel bacterial–eukaryotic signaling

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The common language of bacteria and higher life forms is a lexicon of small molecules that the research community is only beginning to decipher. While many new signaling molecules have been discovered in recent years, the identification of their targets is mostly lagging. This review will focus on the latest chemical-probe based research aimed at understanding how bacteria interact chemically with mammals and plants. In general, chemical biology strategies remain under-utilized in this complex field of research, with a few key exceptions, and we hope that this review encourages others to implement these techniques in their research. Specifically, we highlight the chemical biology techniques used in recent studies, especially activity-based protein profiling, that have been applied to unravel the chemical mechanisms of interkingdom interactions.

Graphical abstract: Chemical strategies to unravel bacterial–eukaryotic signaling

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Publication details

The article was received on 16 Aug 2017 and first published on 20 Dec 2017

Article type: Review Article
DOI: 10.1039/C7CS00606C
Citation: Chem. Soc. Rev., 2018,47, 1761-1772

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    Chemical strategies to unravel bacterial–eukaryotic signaling

    R. Gregor, S. David and M. M. Meijler, Chem. Soc. Rev., 2018, 47, 1761
    DOI: 10.1039/C7CS00606C

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