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Issue 11, 2018
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Reactions of secondary propargylamines with heteroallenes for the synthesis of diverse heterocycles

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Abstract

This focused review aims to summarize recent developments in the processes involving additions of secondary propargylamines to various heteroallenes and subsequent transition metal-catalyzed or electrophile-mediated cyclizations. The utility of this convenient and tunable strategy spans from the carbon dioxide fixation and target-oriented synthesis of complex natural and biologically active products to the generation of extended synthetic libraries of diverse oxygen-, nitrogen- and sulfur-containing heterocycles. For comparative purposes, the analogous transformations of propargylic alcohols are also highlighted in this account.

Graphical abstract: Reactions of secondary propargylamines with heteroallenes for the synthesis of diverse heterocycles

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Article information


Submitted
25 Oct 2017
First published
16 Mar 2018

Chem. Soc. Rev., 2018,47, 3861-3898
Article type
Review Article

Reactions of secondary propargylamines with heteroallenes for the synthesis of diverse heterocycles

V. A. Peshkov, O. P. Pereshivko, A. A. Nechaev, A. A. Peshkov and E. V. Van der Eycken, Chem. Soc. Rev., 2018, 47, 3861
DOI: 10.1039/C7CS00065K

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