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Issue 17, 2018
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Halogen-like properties of the Al13 cluster mimicking astatine

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Astatine-211 is considered to be one of the most promising alpha-emitters in targeted alpha therapy (TAT). However, its development has been hindered by its not so well understood chemistry. Hence, any attempt to understanding it better is imperative. Here, we show through DFT calculations that the neutral endohedral Al13 cluster follows a reactivity pattern very similar to At, more than any other halogen. The halogen and alkali bonding with Al13 and At presented a strong similarity in their charge transfer processes. Moreover, upon the interchange of At with Al13, we found a stable configuration of the compound corresponding to the astatination of aryliodonium salts, which have been considered as possible precursors for the synthesis of 211At-labeled tracers. Our results provide promising proof of concept that the Al13 cluster mimics the behaviour of At and might help in better understanding its chemistry and in streamlining the chemical processes of radiolabeling biomolecules.

Graphical abstract: Halogen-like properties of the Al13 cluster mimicking astatine

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Publication details

The article was received on 23 Jan 2018, accepted on 04 Apr 2018 and first published on 04 Apr 2018

Article type: Communication
DOI: 10.1039/C8CP00494C
Phys. Chem. Chem. Phys., 2018,20, 11549-11553

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    Halogen-like properties of the Al13 cluster mimicking astatine

    B. Molina, J. R. Soto and J. J. Castro, Phys. Chem. Chem. Phys., 2018, 20, 11549
    DOI: 10.1039/C8CP00494C

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