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Construction of micro/nano structured surface on β-TCP/CaSiO3 bioceramic promotes osteogenic differentiation of mBMSCs

Abstract

Cellular behavior is a result of homologous responses to biomaterials especially the surface. An effective way to elicit a desired biological response is to employ micro/nano structured construction for biomaterial surface design, while the brittleness of inorganic materials usually hinders structure regulation. In this study, a micro/nano structured surface was fabricated using a hydrothermal treatment. The precursor β-tricalcium phosphate was mixed with CaSiO3 as a “crystal seed” in a simple reaction that did not require crystal regulation. The resulting micro/nano structured surface was a hybrid structure containing nanowires, microrods, and rod clusters. The in vitro cellular experiments proliferation, cytotoxicity and osteo differentiation indicated that the hierarchical micro/nano structured surfaces alleviated material cytotoxicity, improved cell proliferation, and effectively promoted osteogenic differentiation of mouse bone mesenchymal stem cells. These results suggested that the simplified surface treatment could be an efficient way to improve cell biological response to inorganic biomaterials.

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Supplementary files

Publication details

The article was received on 08 Oct 2018, accepted on 05 Nov 2018 and first published on 10 Nov 2018


Article type: Paper
DOI: 10.1039/C8CE01711E
Citation: CrystEngComm, 2018, Accepted Manuscript
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    Construction of micro/nano structured surface on β-TCP/CaSiO3 bioceramic promotes osteogenic differentiation of mBMSCs

    L. xiao, N. Zhao, X. Guo, H. duan, J. Diao, Y. dong and Y. Wang, CrystEngComm, 2018, Accepted Manuscript , DOI: 10.1039/C8CE01711E

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