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Issue 41, 2018
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Co-crystallization of anti-inflammatory pharmaceutical contaminants and rare carboxylic acid–pyridine supramolecular synthon breakdown

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Abstract

The reliability of supramolecular synthons in co-crystals involving naproxen and mefenamic acid is investigated. The carboxylic acid⋯pyridine synthon is exceptionally reliable; however, we observe synthon breakdown and a rare pyridyl dimer in a co-crystal with mefenamic acid. A Cambridge Structural Database survey supports the rarity of this motif in acid–bipyridine co-crystals.

Graphical abstract: Co-crystallization of anti-inflammatory pharmaceutical contaminants and rare carboxylic acid–pyridine supramolecular synthon breakdown

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Publication details

The article was received on 03 Sep 2018, accepted on 28 Sep 2018 and first published on 28 Sep 2018


Article type: Communication
DOI: 10.1039/C8CE01492B
Citation: CrystEngComm, 2018,20, 6377-6381
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    Co-crystallization of anti-inflammatory pharmaceutical contaminants and rare carboxylic acid–pyridine supramolecular synthon breakdown

    Q. Zheng, S. L. Rood, D. K. Unruh and K. M. Hutchins, CrystEngComm, 2018, 20, 6377
    DOI: 10.1039/C8CE01492B

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