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Role of hydrogen bonding in cocrystals and coamorphous solids: indapamide as a case study

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Abstract

The stronger sulfonamide–pyridine (SO2NH2⋯N-Py) and sulfonamide–carboxamide (SO2NH2⋯O[double bond, length as m-dash]C–NH) hydrogen bonds direct the formation of cocrystals, while the weaker sulfonamide–amine (SO2NH2⋯N–H) hydrogen bond results in coamorphous products. IDP–PIP and IDP–ARG coamorphous solids exhibit remarkable stability under accelerated conditions.

Graphical abstract: Role of hydrogen bonding in cocrystals and coamorphous solids: indapamide as a case study

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Publication details

The article was received on 02 Jul 2018, accepted on 01 Aug 2018 and first published on 07 Aug 2018


Article type: Communication
DOI: 10.1039/C8CE01075G
Citation: CrystEngComm, 2018, Advance Article
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    Role of hydrogen bonding in cocrystals and coamorphous solids: indapamide as a case study

    S. Allu, K. Suresh, G. Bolla, M. K. C. Mannava and A. Nangia, CrystEngComm, 2018, Advance Article , DOI: 10.1039/C8CE01075G

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