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Issue 39, 2018
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Hygroscopicity of lithium coordination polymers and their solid solutions

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Abstract

Coordination polymers (CPs) of active pharmaceutical ingredients (APIs) are relatively rare, though recent studies show how these forms can afford improved solubility and stability. Here, the hygroscopicity of two coordination polymers of lithium and their solid solutions is investigated. The two systems exhibit different behaviour, impacting their potential utility as drug substances. In particular, the solid solutions of {[(PRO)Li(MBNZ)1−x(BNZ)x]}n (1x) show lower stability than both the pure compounds whereas in the solid solutions of {[Li2(SUC)1−x(MAL)x]}n (2x), the hygroscopicity varies more regularly with composition.

Graphical abstract: Hygroscopicity of lithium coordination polymers and their solid solutions

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Publication details

The article was received on 31 May 2018, accepted on 27 Jul 2018 and first published on 27 Jul 2018


Article type: Communication
DOI: 10.1039/C8CE00905H
Citation: CrystEngComm, 2018,20, 5940-5944
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    Hygroscopicity of lithium coordination polymers and their solid solutions

    M. Lestari, M. Lusi, A. O'Leary, D. O'Nolan and M. J. Zaworotko, CrystEngComm, 2018, 20, 5940
    DOI: 10.1039/C8CE00905H

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