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Issue 37, 2018
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Lack of dependence of mechanical properties of baicalein cocrystals on those of the constituent components

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Abstract

Commercial baicalein (α form) exhibits deficient tabletability. Cocrystals of baicalein with nicotinamide, caffeine, and isoniazid were all shown to display excellent tabletability, despite the three coformers having high, medium, and poor tabletability, respectively. A crystal structure analysis using the energy framework approach revealed that the superior tabletability of these cocrystals always correlated with structural features rendering high plasticity irrespective of the coformer involved.

Graphical abstract: Lack of dependence of mechanical properties of baicalein cocrystals on those of the constituent components

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Article information


Submitted
14 May 2018
Accepted
17 Jul 2018
First published
17 Jul 2018

CrystEngComm, 2018,20, 5486-5489
Article type
Communication

Lack of dependence of mechanical properties of baicalein cocrystals on those of the constituent components

L. Liu, C. Wang, J. Dun, A. H. L. Chow and C. C. Sun, CrystEngComm, 2018, 20, 5486
DOI: 10.1039/C8CE00787J

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