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Remarkable decrease in stiffness of aspirin crystals upon reducing crystal size to nanoscale dimensions via sonochemistry

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Abstract

Nano-dimensional single crystals of acetylsalicylic acid (aspirin) Form I are generated through sonocrystallization and are shown to exhibit Young's modulus values in the MPa range, which is significantly softer (5-fold reduction) than macro-dimensional single crystals. The change is attributed to structural consequences of the size-dependent surface-to-volume ratio effect, particularly as related to intermolecular forces.

Graphical abstract: Remarkable decrease in stiffness of aspirin crystals upon reducing crystal size to nanoscale dimensions via sonochemistry

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Publication details

The article was received on 10 May 2018, accepted on 12 Jun 2018 and first published on 19 Jun 2018


Article type: Communication
DOI: 10.1039/C8CE00764K
Citation: CrystEngComm, 2018, Advance Article
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    Remarkable decrease in stiffness of aspirin crystals upon reducing crystal size to nanoscale dimensions via sonochemistry

    K. M. Hutchins, T. P. Rupasinghe, S. M. Oburn, K. K. Ray, A. V. Tivanski and L. R. MacGillivray, CrystEngComm, 2018, Advance Article , DOI: 10.1039/C8CE00764K

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