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Issue 36, 2018
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Pharmaceutical cocrystallization: an effective approach to modulate the physicochemical properties of solid-state drugs

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Abstract

Pharmaceutical cocrystallization affords an opportunity to modify the physicochemical properties of a solid-state drug without covalent modification of its molecular structure. This review presents an update on various applications of pharmaceutical cocrystallization with considerations on both cocrystals and salts, focusing on the property modification relevant to clinical efficacy and safety, and manufacturability of drugs. Some prominent examples of drug cocrystals/salts, which exhibit improved solubility and/or permeability and pharmacokinetics, stability and mechanic properties, are highlighted.

Graphical abstract: Pharmaceutical cocrystallization: an effective approach to modulate the physicochemical properties of solid-state drugs

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Publication details

The article was received on 02 May 2018, accepted on 10 Aug 2018 and first published on 21 Aug 2018


Article type: Highlight
DOI: 10.1039/C8CE00707A
Citation: CrystEngComm, 2018,20, 5292-5316

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    Pharmaceutical cocrystallization: an effective approach to modulate the physicochemical properties of solid-state drugs

    X. Dai, J. Chen and T. Lu, CrystEngComm, 2018, 20, 5292
    DOI: 10.1039/C8CE00707A

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