Issue 36, 2018

Pharmaceutical cocrystallization: an effective approach to modulate the physicochemical properties of solid-state drugs

Abstract

Pharmaceutical cocrystallization affords an opportunity to modify the physicochemical properties of a solid-state drug without covalent modification of its molecular structure. This review presents an update on various applications of pharmaceutical cocrystallization with considerations on both cocrystals and salts, focusing on the property modification relevant to clinical efficacy and safety, and manufacturability of drugs. Some prominent examples of drug cocrystals/salts, which exhibit improved solubility and/or permeability and pharmacokinetics, stability and mechanic properties, are highlighted.

Graphical abstract: Pharmaceutical cocrystallization: an effective approach to modulate the physicochemical properties of solid-state drugs

Article information

Article type
Highlight
Submitted
02 May 2018
Accepted
10 Aug 2018
First published
21 Aug 2018

CrystEngComm, 2018,20, 5292-5316

Pharmaceutical cocrystallization: an effective approach to modulate the physicochemical properties of solid-state drugs

X. Dai, J. Chen and T. Lu, CrystEngComm, 2018, 20, 5292 DOI: 10.1039/C8CE00707A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements