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Solid-state characterization and solubility enhancement of apremilast drug-drug cocrystals

Abstract

Three isostructural cocrystals of apremilast, a novel anti-psoriasis oral agent, with nicotinamide, caffeine, and acetylsalicylic acid were successfully designed and synthesized. Both apparent solubility and intrinsic dissolution rate of apremilast in pH 2.0 buffer have been improved via the formation of cocrystals.

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Publication details

The article was received on 28 Apr 2018, accepted on 09 Aug 2018 and first published on 09 Aug 2018


Article type: Communication
DOI: 10.1039/C8CE00689J
Citation: CrystEngComm, 2018, Accepted Manuscript
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    Solid-state characterization and solubility enhancement of apremilast drug-drug cocrystals

    F. Wang, Q. Zhang, Z. Zhang, X. Gong, J. Wang and X. Mei, CrystEngComm, 2018, Accepted Manuscript , DOI: 10.1039/C8CE00689J

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