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Issue 39, 2018
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Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals

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Abstract

Three isostructural cocrystals of apremilast, a novel anti-psoriasis oral agent, with nicotinamide, caffeine, and acetylsalicylic acid were successfully designed and synthesized. Both the apparent solubility and intrinsic dissolution rate of apremilast in a pH 2.0 buffer have been improved via the formation of cocrystals.

Graphical abstract: Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals

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Publication details

The article was received on 28 Apr 2018, accepted on 09 Aug 2018 and first published on 09 Aug 2018


Article type: Communication
DOI: 10.1039/C8CE00689J
Citation: CrystEngComm, 2018,20, 5945-5948
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    Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals

    F. Wang, Q. Zhang, Z. Zhang, X. Gong, J. Wang and X. Mei, CrystEngComm, 2018, 20, 5945
    DOI: 10.1039/C8CE00689J

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