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Issue 24, 2018
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Structural motifs in salts of sulfathiazole: implications for design of salt forms in pharmaceuticals APIs

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Abstract

The creation of salts is a frequently used approach for the modification of physicochemical properties of an active pharmaceutical ingredient. Despite the frequency of application, there has been little research into the structural–property relationships of the final material and the nature of the counterion present. This work reports on five new salts of sulfathiazole and compares the energetics of the intermolecular interactions with variation in the crystal packing motifs.

Graphical abstract: Structural motifs in salts of sulfathiazole: implications for design of salt forms in pharmaceuticals APIs

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Article information


Submitted
16 Apr 2018
Accepted
29 May 2018
First published
29 May 2018

CrystEngComm, 2018,20, 3428-3434
Article type
Paper

Structural motifs in salts of sulfathiazole: implications for design of salt forms in pharmaceuticals APIs

C. C. Seaton, R. R. Thomas, E. A. A. Essifaow, E. Nauha, T. Munshi and I. J. Scowen, CrystEngComm, 2018, 20, 3428
DOI: 10.1039/C8CE00606G

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