Jump to main content
Jump to site search

Issue 16, 2019
Previous Article Next Article

Photoactive chelates for radiolabelling proteins

Author affiliations


Photochemical reactions are an attractive foundation for the synthesis of radiolabelled antibodies, immunoglobulin fragments and other proteins/peptides. The synthesis, 68Ga-radiochemistry and photochemical reactivity of three macrocyclic chelates functionalised with an arylazide group is described. Experiments with trastuzumab confirmed that photoradiochemistry facilitates fast, one-pot synthesis of radiolabelled proteins.

Graphical abstract: Photoactive chelates for radiolabelling proteins

Back to tab navigation

Supplementary files

Article information

04 Dec 2018
21 Dec 2018
First published
21 Dec 2018

Chem. Commun., 2019,55, 2257-2260
Article type

Photoactive chelates for radiolabelling proteins

L. S. Eichenberger, M. Patra and J. P. Holland, Chem. Commun., 2019, 55, 2257
DOI: 10.1039/C8CC09660K

Social activity

Search articles by author