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Synthesis and Nitric Oxide Releasing Properties of Novel Fluoro S-Nitrosothiols

Abstract

A series of new fluoro S-nitrosothiols is reported as potential nitric oxide (NO) donors. A three-step synthesis and the NO releasing kinetic profiles of these species are presented. The stoichiometric release of NO, with the clean formation of corresponding disulfides, confirms that these new species can facilitate their application as NO donors for various applications including creating novel antimicrobial and thromboresistant fluoropolymer-based medical devices.

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Publication details

The article was received on 07 Nov 2018, accepted on 04 Dec 2018 and first published on 04 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC08868C
Citation: Chem. Commun., 2018, Accepted Manuscript
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    Synthesis and Nitric Oxide Releasing Properties of Novel Fluoro S-Nitrosothiols

    Y. Zhou , J. Tan, Y. Dai, Y. Yu, Q. Zhang and M. E. Meyerhoff, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC08868C

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