Rhodium(iii)-catalyzed sulfonamide directed ortho C–H carbenoid functionalization via metal carbene migratory insertion

Abstract

A rhodium(III)-catalyzed sulfonamide directed ortho C–H carbenoid functionalization has been developed with good yields. This method is attractive due to its broad substrate scope, and enables derivation of diverse biologically active sulfonamide structures and late-stage modification of sulfa drugs.