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Issue 98, 2018
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A pH-driven ring translocation switch against cancer cells

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Abstract

A molecular switch built with cucurbit[7]uril and a 3-station viologen-phenylene-imidazole compound exhibited pH actuated ring translocation with high fatigue resistance (up to 102 cycles). The switch movement was harnessed toward selectively masking the toxicity of the viologen fragment at neutral pH near non-cancerous cells, while exposing it at acid pH near cancer cells.

Graphical abstract: A pH-driven ring translocation switch against cancer cells

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Supplementary files

Article information


Submitted
30 Oct 2018
Accepted
14 Nov 2018
First published
15 Nov 2018

Chem. Commun., 2018,54, 13825-13828
Article type
Communication

A pH-driven ring translocation switch against cancer cells

Q. Cheng, H. Yin, R. Rosas, D. Gigmes, O. Ouari, R. Wang, A. Kermagoret and D. Bardelang, Chem. Commun., 2018, 54, 13825
DOI: 10.1039/C8CC08681H

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