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A mitochondria-targeting photothermogenic nanozyme for MRI-guided mild photothermal therapy

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Abstract

Iridium complexes were used as a mitochondria-targeting agent to modify the surface of a photothermogenic nanozyme Fe3O4 nanoparticles (Ir@Fe3O4 NPs). Upon NIR irradiation, Ir@Fe3O4 NPs increase the localized temperature to 42 °C which accelerates the catalysis of ˙OH production from H2O2 resulting in excellent mild photothermal therapy.

Graphical abstract: A mitochondria-targeting photothermogenic nanozyme for MRI-guided mild photothermal therapy

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Publication details

The article was received on 26 Oct 2018, accepted on 27 Nov 2018 and first published on 27 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC08570F
Citation: Chem. Commun., 2018, Advance Article
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    A mitochondria-targeting photothermogenic nanozyme for MRI-guided mild photothermal therapy

    K. Qiu, J. Wang, T. W. Rees, L. Ji, Q. Zhang and H. Chao, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC08570F

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