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Metal free direct C(sp2)–H arylaminations using nitrosoarenes to 2-hydroxy-di(het)aryl amines as multifunctional Aβ-aggregation modulators

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Abstract

An unprecedented metal free arylamination reaction involving nitrosoarenes as the electrophilic aminating agents is reported. The direct arylamination of a broad range of substrates, such as naphthols, hydroxyquinolines, hydroxyquinones, coumarins and 1,3-cyclohexadienones was achieved under operationally simple and mild conditions without the aid of additional reagents/steps for N–O bond reduction. Interestingly, novel 2-hydroxydiaryl amines were found to act as Aβ-aggregation inhibitors.

Graphical abstract: Metal free direct C(sp2)–H arylaminations using nitrosoarenes to 2-hydroxy-di(het)aryl amines as multifunctional Aβ-aggregation modulators

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Publication details

The article was received on 23 Oct 2018, accepted on 23 Nov 2018 and first published on 23 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC08470J
Citation: Chem. Commun., 2018, Advance Article
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    Metal free direct C(sp2)–H arylaminations using nitrosoarenes to 2-hydroxy-di(het)aryl amines as multifunctional Aβ-aggregation modulators

    S. K. Roy, A. Tiwari, M. Saleem and C. K. Jana, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC08470J

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