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Light-enhanced hypoxia-responsive nanoparticles for deep tumor penetration and combined chemo-photodynamic therapy

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Abstract

Herein, we report a light-enhanced hypoxia-responsive nanoparticle for synergic treatment of solid tumors. The conversion of oxygen in the tumor exterior induced ROS and the continuous consumption of oxygen amplified the hypoxia conditions in the tumor, which enhanced the surface-to-core penetration of nanoparticles into the hypoxia central tissue.

Graphical abstract: Light-enhanced hypoxia-responsive nanoparticles for deep tumor penetration and combined chemo-photodynamic therapy

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Publication details

The article was received on 23 Oct 2018, accepted on 28 Oct 2018 and first published on 30 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC08445A
Citation: Chem. Commun., 2018, Advance Article
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    Light-enhanced hypoxia-responsive nanoparticles for deep tumor penetration and combined chemo-photodynamic therapy

    Z. Li, M. Wu, H. Bai, X. Liu and G. Tang, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC08445A

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