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Method to directly assay circRNA in real sample

Abstract

A method to directly assay circular RNA (circRNA) is proposed in this work by utilizing the ‘microRNA (miRNA) sponge’ nature of circRNA and by taking the advantage of duplex-specific nuclease. Moreover, miRNA absorption sites-mediated hairpin DNA unfolding and nuclease-assisted target recycling has also been designed in this method to amplify signal readout, thus sensitive assay of circRNA can be achieved in real sample.

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Supplementary files

Publication details

The article was received on 17 Oct 2018, accepted on 02 Nov 2018 and first published on 03 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC08319C
Citation: Chem. Commun., 2018, Accepted Manuscript
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    Method to directly assay circRNA in real sample

    G. Li, J. Jiao, H. Shi, A. Sheng, T. Gao, X. Yang and Y. Shu, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC08319C

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