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Issue 95, 2018
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A method to directly assay circRNA in real samples

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Abstract

A method to directly assay circular RNA (circRNA) is proposed in this work by utilizing the ‘microRNA (miRNA) sponge’ nature of circRNA and by taking the advantage of duplex-specific nuclease. Moreover, miRNA absorption site-mediated hairpin DNA unfolding and nuclease-assisted target recycling have also been designed in this method to amplify the signal readout, thus sensitive assay of circRNA can be achieved in real samples.

Graphical abstract: A method to directly assay circRNA in real samples

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Supplementary files

Publication details

The article was received on 17 Oct 2018, accepted on 02 Nov 2018 and first published on 03 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC08319C
Citation: Chem. Commun., 2018,54, 13451-13454

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    A method to directly assay circRNA in real samples

    J. Jiao, T. Gao, H. Shi, A. Sheng, Y. Xiang, Y. Shu and G. Li, Chem. Commun., 2018, 54, 13451
    DOI: 10.1039/C8CC08319C

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