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Ultrasensitive SERS detection of highly homologous miRNAs by generating 3D organic-nanoclusters and a functionalized chip with locked nucleic acid probes

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Abstract

Herein, a new finding is reported that 3D organic-nanoclusters (3DONs) with superior SERS properties as an original reporter could accurately and sensitively distinguish microRNAs (miRNAs) with highly similar sequences, even with a single-nucleotide difference, as a result of a functionalized chip with locked nucleic acid probes (LNAP-chip) and rolling circle replication (RCA). Furthermore, the innovative SERS-method could be used to broadly discriminate cancer cells from normal cells and evaluate changes in the expression levels of intracellular miRNAs.

Graphical abstract: Ultrasensitive SERS detection of highly homologous miRNAs by generating 3D organic-nanoclusters and a functionalized chip with locked nucleic acid probes

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Publication details

The article was received on 15 Oct 2018, accepted on 06 Nov 2018 and first published on 06 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC08231F
Citation: Chem. Commun., 2018, Advance Article
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    Ultrasensitive SERS detection of highly homologous miRNAs by generating 3D organic-nanoclusters and a functionalized chip with locked nucleic acid probes

    M. Zhu, Z. Sun, Z. Zhang and S. Zhang, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC08231F

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