A single-atom Fe–N4 catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection

Wenjie Ma; Junjie Mao; Xiaoti Yang; Cong Pan; Wenxing Chen; Ming Wang; Ping Yu; Lanqun Mao; Yadong Li

doi:10.1039/C8CC08116F

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A single-atom Fe–N₄ catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection†

Wenjie Ma,‡^ab Junjie Mao,‡^c Xiaoti Yang,^ab Cong Pan,^ab Wenxing Chen,^d Ming Wang,^ab Ping Yu,^ab Lanqun Mao

*^ab and Yadong Li

Author affiliations

* Corresponding authors

^a Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences (CAS), CAS Research/Education Center for Excellence in Molecule Science, Beijing 100190, China
E-mail: lqmao@iccas.ac.cn

^b University of Chinese Academy of Sciences, Beijing 100049, China

^c College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, China

^d Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China

^e Department of Chemistry, Tsinghua University, Beijing 100084, China

Abstract

Atomically dispersed Fe–N₄ sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells.

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Article information

DOI: https://doi.org/10.1039/C8CC08116F
Article type: Communication
Submitted: 10 Oct 2018
Accepted: 19 Nov 2018
First published: 19 Nov 2018

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Chem. Commun., 2019,55, 159-162

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A single-atom Fe–N₄ catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection

W. Ma, J. Mao, X. Yang, C. Pan, W. Chen, M. Wang, P. Yu, L. Mao and Y. Li, Chem. Commun., 2019, 55, 159 DOI: 10.1039/C8CC08116F

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Chemical Communications