Jump to main content
Jump to site search

Issue 100, 2018
Previous Article Next Article

Copper-catalyzed, silver-mediated formal [3+2] cycloaddition of simple alkynes with β-ketoesters through propargylic C(sp3)–H functionalization

Author affiliations

Abstract

A copper-catalyzed propargylic [3+2] cycloaddition of simple alkynes with β-ketoesters through the propargylic C(sp3)–H functionalization has been realized. Under catalysis by CuI in combination with 1,10-phenanthroline hydrate as the ligand and Ag2CO3 as a bifunctional reagent (oxidant and base), the reaction proceeds smoothly with a broad substrate scope, thus providing a variety of highly functionalized furans in moderate to high yields. This represents the first successful example of the catalytic propargylic cycloaddition of simple alkynes with bisnucleophiles based on the propargylic C(sp3)–H functionalization strategy.

Graphical abstract: Copper-catalyzed, silver-mediated formal [3+2] cycloaddition of simple alkynes with β-ketoesters through propargylic C(sp3)–H functionalization

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Oct 2018, accepted on 22 Nov 2018 and first published on 22 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC08013E
Citation: Chem. Commun., 2018,54, 14100-14103
  •   Request permissions

    Copper-catalyzed, silver-mediated formal [3+2] cycloaddition of simple alkynes with β-ketoesters through propargylic C(sp3)–H functionalization

    Z. Liu and X. Hu, Chem. Commun., 2018, 54, 14100
    DOI: 10.1039/C8CC08013E

Search articles by author

Spotlight

Advertisements