Jump to main content
Jump to site search

Issue 100, 2018
Previous Article Next Article

Mn(ii)-catalysed alkylation of methylene ketones with alcohols: direct access to functionalised branched products

Author affiliations

Abstract

Herein an operationally simple alkylation of methylene ketones with primary alcohols is reported. Use of an inexpensive and earth abundant Mn/1,10-phenanthroline system enables direct access to a series of functionalised branched ketones including one-pot sequential double alkylation and Alzheimer's drug donepezil. Preliminary mechanistic investigation, determination of the rate and order of reactions and deuterium labeling experiments support the participation of the hydrogen-borrowing strategy for the ketone alkylation.

Graphical abstract: Mn(ii)-catalysed alkylation of methylene ketones with alcohols: direct access to functionalised branched products

Back to tab navigation

Supplementary files

Article information


Submitted
07 Oct 2018
Accepted
25 Oct 2018
First published
25 Oct 2018

Chem. Commun., 2018,54, 14069-14072
Article type
Communication

Mn(II)-catalysed alkylation of methylene ketones with alcohols: direct access to functionalised branched products

L. M. Kabadwal, J. Das and D. Banerjee, Chem. Commun., 2018, 54, 14069
DOI: 10.1039/C8CC08010K

Social activity

Search articles by author

Spotlight

Advertisements