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Trisubstituted alkenes with a single activator as dipolarophiles in a highly diastereo- and enantioselective [3+2] cycloaddition with vinyl epoxides under Pd-catalysis

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Abstract

1,1,2-Trisubstituted alkenes with a single strongly electronic withdrawing activator, which are unreactive electron-deficient alkenes in transition metal-catalyzed [3+2] cycloaddition with vinyl three-membered heterocycles, were used in the Pd-catalyzed asymmetric cycloaddition of vinyl epoxides, affording multifunctionalized tetrahydrofurans in high yields with high diastereo- and enantioselectivities.

Graphical abstract: Trisubstituted alkenes with a single activator as dipolarophiles in a highly diastereo- and enantioselective [3+2] cycloaddition with vinyl epoxides under Pd-catalysis

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Publication details

The article was received on 07 Oct 2018, accepted on 29 Oct 2018 and first published on 31 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC07996J
Citation: Chem. Commun., 2018, Advance Article
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    Trisubstituted alkenes with a single activator as dipolarophiles in a highly diastereo- and enantioselective [3+2] cycloaddition with vinyl epoxides under Pd-catalysis

    J. Du, Y. Jiang, J. Suo, W. Wu, X. Liu, D. Chen, C. Ding, Y. Wei and X. Hou, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC07996J

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