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Mild dynamic kinetic resolution of amines by coupled visible-light photoredox and enzyme catalysis

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Abstract

Herein, we described photoenzymatic dynamic kinetic resolution (DKR) of amines under mild conditions. The racemization of amines via a photoredox-mediated hydrogen atom transfer (HAT) protocol in conjunction with an enzyme catalyst to achieve the DKR of amines allows a variety of primary amines to be converted into a single enantiomer in high yield and with excellent enantioselectivity. Notably, this protocol can also be extended to 1,4-diamine derivatives with high levels of diastereo- and enantioselectivity.

Graphical abstract: Mild dynamic kinetic resolution of amines by coupled visible-light photoredox and enzyme catalysis

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Publication details

The article was received on 08 Oct 2018, accepted on 31 Oct 2018 and first published on 01 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC07990K
Citation: Chem. Commun., 2018, Advance Article
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    Mild dynamic kinetic resolution of amines by coupled visible-light photoredox and enzyme catalysis

    Q. Yang, F. Zhao, N. Zhang, M. Liu, H. Hu, J. Zhang and S. Zhou, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC07990K

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