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Pelargonidin-3-O-rutinoside as a novel α-glucosidase inhibitor for improving postprandial hyperglycemia

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Abstract

A novel strategy for the isolation of anthocyanins was developed by a combination of high-speed countercurrent chromatography (HSCCC) and HPLC techniques. Using this strategy, a novel α-glucosidase inhibitor (pelargonidin-3-O-rutinoside, a natural anthocyanin) was isolated from strawberries. Structural determinants for inhibition of α-glucosidase by Pg3R and the SAR of natural anthocyanins were revealed in detail by enzymatic kinetics and molecular docking analysis.

Graphical abstract: Pelargonidin-3-O-rutinoside as a novel α-glucosidase inhibitor for improving postprandial hyperglycemia

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Publication details

The article was received on 06 Oct 2018, accepted on 25 Oct 2018 and first published on 25 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC07985D
Citation: Chem. Commun., 2018, Advance Article
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    Pelargonidin-3-O-rutinoside as a novel α-glucosidase inhibitor for improving postprandial hyperglycemia

    Y. Xu, L. Xie, J. Xie, Y. Liu and W. Chen, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC07985D

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