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Issue 99, 2018
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Displacement chemistry-based nanopore analysis of nucleic acids in complicated matrices

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Abstract

To overcome the effect of other components of complicated biological samples on nanopore stochastic sensing, displacement chemical reaction was utilized to selectively extract the target nucleic acid from whole blood. Given its simplicity and high sensitivity for detecting nucleic acids, our developed displacement chemistry-based nanopore sensing strategy offers the potential for fieldable/point-of-care diagnostic applications.

Graphical abstract: Displacement chemistry-based nanopore analysis of nucleic acids in complicated matrices

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Publication details

The article was received on 04 Oct 2018, accepted on 19 Nov 2018 and first published on 19 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC07944G
Citation: Chem. Commun., 2018,54, 13977-13980

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    Displacement chemistry-based nanopore analysis of nucleic acids in complicated matrices

    L. Wang, X. Chen, S. Zhou, G. M. Roozbahani, Y. Zhang, D. Wang and X. Guan, Chem. Commun., 2018, 54, 13977
    DOI: 10.1039/C8CC07944G

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