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Issue 91, 2018
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Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs

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Abstract

Polymethacrylate-copolymer (PMA) encased lipid-nanodiscs (∼10 nm) and macro-nanodiscs (>15 nm) are used to study Aβ1–40 aggregation. We demonstrate that PMA-nanodiscs form a ternary association with Aβ and regulate its aggregation kinetics by trapping intermediates. Results demonstrating the reduced neurotoxicity of nanodisc-bound Aβ oligomers are also reported.

Graphical abstract: Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs

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Publication details

The article was received on 03 Oct 2018, accepted on 22 Oct 2018 and first published on 22 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC07921H
Citation: Chem. Commun., 2018,54, 12883-12886
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    Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs

    B. R. Sahoo, T. Genjo, M. Bekier, S. J. Cox, A. K. Stoddard, M. Ivanova, K. Yasuhara, C. A. Fierke, Y. Wang and A. Ramamoorthy, Chem. Commun., 2018, 54, 12883
    DOI: 10.1039/C8CC07921H

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