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Issue 95, 2018
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Use of an NIR-light-responsive CO nanodonor to improve the EPR effect in photothermal cancer treatment

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Abstract

The carbon monoxide (CO)-carrying palladium nanosheet (PdNS-CO) was exploited as a photothermally triggered donor of CO. Irradiating material containing PdNS-CO with 808 nm-wavelength light caused a rapid heating of the material, triggering a release of CO. The enhanced permeability and retention (EPR) effect was found to be improved by such released CO and resulted in an increase in the accumulation of PdNS-CO at tumors and hence promoted its use in photothermal therapy (PTT) using a low laser power density.

Graphical abstract: Use of an NIR-light-responsive CO nanodonor to improve the EPR effect in photothermal cancer treatment

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Publication details

The article was received on 02 Oct 2018, accepted on 01 Nov 2018 and first published on 02 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC07873D
Citation: Chem. Commun., 2018,54, 13403-13406

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    Use of an NIR-light-responsive CO nanodonor to improve the EPR effect in photothermal cancer treatment

    C. Wang, Y. Li, X. Shi, J. Zhou, L. Zhou and S. Wei, Chem. Commun., 2018, 54, 13403
    DOI: 10.1039/C8CC07873D

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