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An integrated immobilization strategy manipulates dual active centers to boost enantioselective tandem reactions

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Abstract

Manipulation of dual active centers via an integrated immobilization strategy can overcome the restriction of homogeneous catalysis in a sequential organic transformation. Herein, by utilizing hollow-shell-structured silica, hydrogen-bonding immobilization via a ship-in-a-bottle synthesis locks a Pd(carbene) center in a nanocage and covalent-bonding immobilization tethers chiral Ru(diamine) centers within the nanochannels, constructing a hetero-bifunctional catalyst. The benefit of this dual center manipulation enables a challenging Suzuki coupling-asymmetric transfer hydrogenation tandem reaction, and the advantage of this process provides various chiral biarylols with enhanced reactivity and enantioselectivity.

Graphical abstract: An integrated immobilization strategy manipulates dual active centers to boost enantioselective tandem reactions

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Publication details

The article was received on 01 Oct 2018, accepted on 23 Oct 2018 and first published on 24 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC07841F
Citation: Chem. Commun., 2018, Advance Article
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    An integrated immobilization strategy manipulates dual active centers to boost enantioselective tandem reactions

    X. Shu, R. Jin, Z. Zhao, T. Cheng and G. Liu, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC07841F

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