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An intracellular diamine oxidase triggered hyperpolarized 129Xe magnetic resonance biosensor

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Abstract

Here, a novel method was developed for suppressing 129Xe signals in cucurbit[6]uril (CB6) until the trigger is activated by a specific enzyme. Due to its noncovalent interactions with amino-groups and CB6, putrescine dihydrochloride (Put) was chosen for blocking interactions between 129Xe and CB6. Upon adding diamine oxidase (DAO), Put was released from CB6 and a 129Xe@CB6 Hyper-CEST signal emerged. This proposed 129Xe biosensor was then tested in small intestinal villus epithelial cells.

Graphical abstract: An intracellular diamine oxidase triggered hyperpolarized 129Xe magnetic resonance biosensor

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Publication details

The article was received on 30 Sep 2018, accepted on 22 Oct 2018 and first published on 23 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC07822J
Citation: Chem. Commun., 2018, Advance Article
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    An intracellular diamine oxidase triggered hyperpolarized 129Xe magnetic resonance biosensor

    B. Zhang, Q. Guo, Q. Luo, X. Zhang, Q. Zeng, L. Zhao, Y. Yuan, W. Jiang, Y. Yang, M. Liu, C. Ye and X. Zhou, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC07822J

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