A highly selective and sensitive fluorescent probe for simultaneously distinguishing and sequentially detecting H2S and various thiol species in solution and in live cells

Dan Qiao; Tangliang Shen; Mengyuan Zhu; Xiao Liang; Lu Zhang; Zheng Yin; Binghe Wang; Luqing Shang

doi:10.1039/C8CC07761D

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A highly selective and sensitive fluorescent probe for simultaneously distinguishing and sequentially detecting H₂S and various thiol species in solution and in live cells†

Dan Qiao,^a Tangliang Shen,^a Mengyuan Zhu,^b Xiao Liang,^a Lu Zhang,^a Zheng Yin,^a Binghe Wang

*^b and Luqing Shang

*^a

Author affiliations

* Corresponding authors

^a College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, P. R. China
E-mail: shanglq@nankai.edu.cn

^b Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, USA
E-mail: wang@gsu.edu

Abstract

A novel dual-channel fluorescent probe (NCR) based on differences in reactivity among H₂S, Cys/Hcy, and GSH was rationally designed for simultaneously distinguishing and sequentially sensing H₂S, Cys/Hcy, and GSH using two emission channels, which also demonstrated that NCR can be used for targeting mitochondria in mammalian cells.

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Article information

DOI: https://doi.org/10.1039/C8CC07761D
Article type: Communication
Submitted: 28 Sep 2018
Accepted: 01 Nov 2018
First published: 01 Nov 2018

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Chem. Commun., 2018,54, 13252-13255

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A highly selective and sensitive fluorescent probe for simultaneously distinguishing and sequentially detecting H₂S and various thiol species in solution and in live cells

D. Qiao, T. Shen, M. Zhu, X. Liang, L. Zhang, Z. Yin, B. Wang and L. Shang, Chem. Commun., 2018, 54, 13252 DOI: 10.1039/C8CC07761D

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Chemical Communications