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Facile preparation of phospholipid–amorphous calcium carbonate hybrid nanoparticles: toward controllable burst drug release and enhanced tumor penetration

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Abstract

A facile solvent diffusion method was developed to prepare phospholipid–amorphous calcium carbonate (ACC) hybrid nanoparticles via a one-pot approach. The hybrid nanoparticles can specifically realize water-responsive burst drug release in cancer cells and potentiate drug penetration into deep tumor tissues for advanced cancer therapy.

Graphical abstract: Facile preparation of phospholipid–amorphous calcium carbonate hybrid nanoparticles: toward controllable burst drug release and enhanced tumor penetration

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Publication details

The article was received on 25 Sep 2018, accepted on 24 Oct 2018 and first published on 25 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC07694D
Citation: Chem. Commun., 2018, Advance Article
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    Facile preparation of phospholipid–amorphous calcium carbonate hybrid nanoparticles: toward controllable burst drug release and enhanced tumor penetration

    C. Wang, X. Liu, S. Chen, F. Hu, J. Sun and H. Yuan, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC07694D

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