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Homogeneous enzyme-free and entropy-driven isothermal fluorescent assay for nucleic acids based on a dual-signal output amplification strategy

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Abstract

Herein, we developed a homogeneous enzyme-free, ultrasensitive and isothermal fluorescent biosensor for nucleic acid detection with dual-signal output to enhance the reaction rate and sensitivity by combining an entropy-driven catalysis strategy with a catalytic hairpin assembly reaction.

Graphical abstract: Homogeneous enzyme-free and entropy-driven isothermal fluorescent assay for nucleic acids based on a dual-signal output amplification strategy

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Publication details

The article was received on 17 Sep 2018, accepted on 12 Oct 2018 and first published on 12 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC07508E
Citation: Chem. Commun., 2018, Advance Article
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    Homogeneous enzyme-free and entropy-driven isothermal fluorescent assay for nucleic acids based on a dual-signal output amplification strategy

    E. Xiong, D. Zhen and L. Jiang, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC07508E

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