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A dual signal amplification nanosensor based on SERS technology for detection of tumor-related DNA

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Abstract

A dual signal amplification method based on surface-enhanced Raman scattering (SERS) is developed by photo-triggered release of SERS probes from mesoporous silica-coated Au nanorods (SiO2@Au) and the use of a specially-designed SERS substrate with an internal reference. Two metal carbonyl (metal-CO) labels (Os-SCO and Re-SCO) are proposed here as novel interference-free labels. Results demonstrate that tumor-related DNA can be quantitatively detected by this reliable and ultra-sensitive SERS platform.

Graphical abstract: A dual signal amplification nanosensor based on SERS technology for detection of tumor-related DNA

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Publication details

The article was received on 14 Sep 2018, accepted on 30 Nov 2018 and first published on 04 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC07461E
Citation: Chem. Commun., 2019, Advance Article
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    A dual signal amplification nanosensor based on SERS technology for detection of tumor-related DNA

    D. Lin, T. Gong, S. Qiu, Q. Wu, C. Tseng, K. V. Kong, G. Chen and R. Chen, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC07461E

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