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Dual-channel near-infrared fluorescent probe for real-time tracking of endogenous γ-glutamyl transpeptidase activity

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Abstract

A curcuminoid difluoroboron-based tumor-targeting GGT-activatable fluorescent probe (Glu-DFB-biotin) is designed, which has remarkable characteristics of dual-channel and light-up near-infrared (NIR) fluorescence. Furthermore, Glu-DFB-biotin can differentiate hepatic cancer cells from normal cells and is successfully employed for real-time tracking of endogenous GGT activity in living cells.

Graphical abstract: Dual-channel near-infrared fluorescent probe for real-time tracking of endogenous γ-glutamyl transpeptidase activity

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Publication details

The article was received on 11 Sep 2018, accepted on 03 Oct 2018 and first published on 04 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC07376G
Citation: Chem. Commun., 2018, Advance Article
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    Dual-channel near-infrared fluorescent probe for real-time tracking of endogenous γ-glutamyl transpeptidase activity

    B. Bai, C. Yan, Y. Zhang, Z. Guo and W. Zhu, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC07376G

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