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Iridium-catalyzed direct asymmetric vinylogous allylic alkylation

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Abstract

The catalytic asymmetric vinylogous allylic alkylation of α,β-unsaturated lactones (including coumarins) was achieved with excellent regio- and enantioselectivity. Transformations of the product were carried out by means of the versatile terminal olefin and lactone moieties. The synthetic application of the present methodology was showcased by the asymmetric synthesis of an advanced synthetic Merck intermediate toward a new drug candidate.

Graphical abstract: Iridium-catalyzed direct asymmetric vinylogous allylic alkylation

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Publication details

The article was received on 06 Sep 2018, accepted on 27 Sep 2018 and first published on 27 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC07249C
Citation: Chem. Commun., 2018, Advance Article
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    Iridium-catalyzed direct asymmetric vinylogous allylic alkylation

    C. Shi, J. Xiao and L. Yin, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC07249C

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