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A cell-penetrating peptide induces the self-reproduction of phospholipid vesicles: understanding the role of the bilayer rigidity

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Abstract

Model lipid vesicles self-reproduce to generate unilamellar daughter vesicles in the presence of a cell-penetrating peptide. Fluorescence lifetime and anisotropy image analysis exquisitely capture the change in the lipid bilayer rigidity throughout the process, whereas a solvation dynamic study delineates the change in the dynamics of the encapsulated water inside the vesicles. Overall, our results provide an experimental underpinning of the role of the lipid bilayer structural changes in self-reproduction, which can exhibit great potential for interpreting the protein–membrane interaction in the emergence of life and for developing new therapeutic strategies.

Graphical abstract: A cell-penetrating peptide induces the self-reproduction of phospholipid vesicles: understanding the role of the bilayer rigidity

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Publication details

The article was received on 04 Sep 2018, accepted on 14 Sep 2018 and first published on 14 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC07176D
Citation: Chem. Commun., 2018, Advance Article
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    A cell-penetrating peptide induces the self-reproduction of phospholipid vesicles: understanding the role of the bilayer rigidity

    P. Banerjee, S. Pal, N. Kundu, D. Mondal and N. Sarkar, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC07176D

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