Issue 81, 2018

A cell-penetrating peptide induces the self-reproduction of phospholipid vesicles: understanding the role of the bilayer rigidity

Abstract

Model lipid vesicles self-reproduce to generate unilamellar daughter vesicles in the presence of a cell-penetrating peptide. Fluorescence lifetime and anisotropy image analysis exquisitely capture the change in the lipid bilayer rigidity throughout the process, whereas a solvation dynamic study delineates the change in the dynamics of the encapsulated water inside the vesicles. Overall, our results provide an experimental underpinning of the role of the lipid bilayer structural changes in self-reproduction, which can exhibit great potential for interpreting the protein–membrane interaction in the emergence of life and for developing new therapeutic strategies.

Graphical abstract: A cell-penetrating peptide induces the self-reproduction of phospholipid vesicles: understanding the role of the bilayer rigidity

Supplementary files

Article information

Article type
Communication
Submitted
04 Sep 2018
Accepted
14 Sep 2018
First published
14 Sep 2018

Chem. Commun., 2018,54, 11451-11454

A cell-penetrating peptide induces the self-reproduction of phospholipid vesicles: understanding the role of the bilayer rigidity

P. Banerjee, S. Pal, N. Kundu, D. Mondal and N. Sarkar, Chem. Commun., 2018, 54, 11451 DOI: 10.1039/C8CC07176D

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