Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 93, 2018
Previous Article Next Article

Evaluation of the photo-degradation of Alzheimer's amyloid fibrils with a label-free approach

Author affiliations

Abstract

Degradation of amyloid-β (Aβ) aggregates has been considered as an attractive therapeutic and preventive strategy against Alzheimer's disease (AD). However, an in situ, real-time, and label-free technique is still lacking to understand the degradation process of Aβ aggregates. In this work, we developed a novel method to quantitatively evaluate the degradation of Aβ fibrils by photoactive meso-tetra(4-sulfonatophenyl)porphyrin under UV irradiation with quartz crystal microbalance (QCM).

Graphical abstract: Evaluation of the photo-degradation of Alzheimer's amyloid fibrils with a label-free approach

Back to tab navigation

Supplementary files

Publication details

The article was received on 04 Sep 2018, accepted on 24 Oct 2018 and first published on 25 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC07164K
Citation: Chem. Commun., 2018,54, 13084-13087

  •   Request permissions

    Evaluation of the photo-degradation of Alzheimer's amyloid fibrils with a label-free approach

    T. Wang, L. Zhang, J. Wang, Y. Feng, E. Xu, X. Mao and L. Liu, Chem. Commun., 2018, 54, 13084
    DOI: 10.1039/C8CC07164K

Search articles by author

Spotlight

Advertisements