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Issue 93, 2018
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Evaluation of the photo-degradation of Alzheimer's amyloid fibrils with a label-free approach

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Abstract

Degradation of amyloid-β (Aβ) aggregates has been considered as an attractive therapeutic and preventive strategy against Alzheimer's disease (AD). However, an in situ, real-time, and label-free technique is still lacking to understand the degradation process of Aβ aggregates. In this work, we developed a novel method to quantitatively evaluate the degradation of Aβ fibrils by photoactive meso-tetra(4-sulfonatophenyl)porphyrin under UV irradiation with quartz crystal microbalance (QCM).

Graphical abstract: Evaluation of the photo-degradation of Alzheimer's amyloid fibrils with a label-free approach

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Publication details

The article was received on 04 Sep 2018, accepted on 24 Oct 2018 and first published on 25 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC07164K
Citation: Chem. Commun., 2018,54, 13084-13087
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    Evaluation of the photo-degradation of Alzheimer's amyloid fibrils with a label-free approach

    T. Wang, L. Zhang, J. Wang, Y. Feng, E. Xu, X. Mao and L. Liu, Chem. Commun., 2018, 54, 13084
    DOI: 10.1039/C8CC07164K

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